Body mass index, frailty and outcome of patients with significant tricuspid regurgitation

Abstract Funding Acknowledgements Type of funding sources: None. Background Body weight is associated with frailty and an independent strong predictor adverse outcomes among patients cardiovascular diseases. Purpose To evaluate how body mass index (BMI) modify the association significant tricuspid regurgitation (TR) poor survival. Methods Consecutive echocardiographic reports linked to clinical data from a tertiary medical center (2007–2021) were reviewed. Patients BMI between 14 45 Kg/m2 included, first echocardiography as case. Significant TR was defined moderate-to-severe or severe. categories included underweight, normal weight, overweight obesity cutoffs 18.5, 25 30, respectively. Frailty stratified into 3 groups. The primary outcome all-cause mortality available for all patients. Multivariable Cox regression interaction analysis models applied. Results Final study population 109,927 median age 65 (IQR 52–76) years whom 63,368 (58%) males. 3,352 (3.1%) had TR. There 2,384 (2%), 39,638 (36%), 43,086 (39%), 24,700 (24%) individuals overweight, obesity, respectively, 3% in each group. During follow-up 4.7 (1.8–8.5) 28,917 (26%) died. Interaction multivariable model demonstrated that survival significantly modified by such differed across groups (not underweight groups, HR 1.27 1.32 1.34 p<.0001 three groups: Figure 1A). not significant, similarly mortality. Sub-analysis 67,188 (61%) who hospitalized, adjustment baseline comorbidities (heart failure, ischemic heart disease, diabetes etc.) yielded similar point estimates main (Figure 1B). Conclusions frailty, whereas it weight. Among patients,